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KMID : 0381919880180020034
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Korean Journal of Microscopy
1988 Volume.18 No. 2 p.34 ~ p.46
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Changes in the Number of Exocrine Granules in Mouse Pancreatic Acinar Cells Induced by Acetylcholine and MNNG in vitro
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Cho Eng-Haeng
Choi Im-Soon
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Abstract
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The stimulation-secretion coupling in the pancreatic acinar cell have been studied by electron microscope. Morphological changes in the cells exhibited the cellular response induced by acetylcholine and MNNG. MNNG, a guanylate cyclase activator, induced the formation of numerous secretory granules in a period after the agent administration. This result suggest that guanylate cyclase potentiated the early sustained response in pancreatic acinar cells stimulated by acetylcholine. Cycloheximide and dibucaine reduced the secretory granules in number during sustained period. In pancreatic acinar cells, the secretion granules were considered to be directly packaged from cisternal space of endoplasmic reticulum.
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